The story starts with an incident taking place in 12th century when Hindus were divided into Saivites and Vaishnavites. Rangarajan Nambi (Kamal.1) is a loyal disciple of Ramanuja Azhwar. King Kulothunga (Napolean - what a fantastic performance!), a follower of Lord Siva, compels Nambi to worship Lord Siva instead of Lord Vishnu but Nambi refuses.The king then orders to throw the statue of Lord vishnu along with Nambi into the sea.
After this first avatar, the movie shifts to the present world America. Govind (Kamal.2)scientist invents a dangerous bio weapon in his lab but wants to destroy the it after realizing its dangerous,but the US Govt and scientists don’t allow him to do that. One fine day, Govind runs away from the lab with the bio weapon but Fletcher (Kamal.3), a former CIA officer turned villian, chases him to get the weapon back to destroy other countries.
The weapon by mistake sent to an Indian address by courier where a 95 year old lady (Kamal.4) receives the parcel. Govind immediately rushes to India and traces down the address followed by Fletcher accompanied by his prostitute cum translator (Mallika Sherawat). The old lady refuses to give the weapon to them without understanding the danger it could cause and puts it inside a statue of Lord Vishnu.
The scientist captures the statue and starts running with it pulling Asin close relative of the old lady, along with.A foolish police officer Balram Naidu (Kamal.5) too is in the race always chasing both these characters.
In between a Punjabi singer (Kamal.5), US President George Bush (Kamal.6), a tall Muslim (Kamal.7), a martial arts trainer (Kamal.8) and a Southern district resident Annachi (Kamal.9) comes.
Finally the tsunami comes to the rescue of the Scientist and destroys the weapon along with drowning Fletcher . The statue of Lord Rangaraja which was immersed in the sea in 12th century also appears on the shore after the tsunami.
